Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
USERS' SCORE
Moderately Good
Based on 31 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Sodium (from Sodium Hyaluronate)
10 mg
< 1 %
Hyaluronic Acid (from Sodium Hyaluronate)
100 mg
†
L-Proline (Free-Form)
100 mg
†
Alpha Lipoic Acid
50 mg
†
Grape Seed Extract (Vitis vinifera)(Standardized for Polyphenols)
25 mg
†
Top Medical Research Studies
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
9
We explored a creative approach to treat rheumatoid arthritis, focusing on a new delivery method for tacrolimus using hyaluronic acid-coated nanogels.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
By targeting inflamed joints specifically, this system reduced unwanted side effects and improved the effectiveness of tacrolimus therapy.
In trials with collagen-induced arthritis mice, the treatment showed impressive results, such as decreased joint swelling and inflammation.
Overall, this suggests that this hyaluronic acid-based delivery system could offer a safer and more effective treatment option for those suffering from rheumatoid arthritis.
Read More
Most Useful Reviews
8.5
Joint mobility improved
74 people found this helpful
I have taken Hyaluronic acid 100 mg from Now for 1.5 years, a tablet daily after meals. I take it after other supplements to improve cartilage quality, joint mobility, and skin hydration while reducing wrinkles. I exercise regularly and maintain an active lifestyle. Hyaluronic acid helps alleviate stress on my joints, and I recommend it for daily use thanks to its quality and performance, especially after the age of 35.
Read More
9
Reduced wrinkles
14 people found this helpful
I really like this product! My joints feel much better, and it's visibly improved my skin, leading to far fewer wrinkles. I've just ordered some facial cream as well; I like it! The delivery from iHerb is outstanding.
Read More
9
Smoother skin
8 people found this helpful
Awesome product!! Two months ago, I purchased hyaluronic acid with collagen and MSM powder to enhance my skin, nails, joints, and cartilage. Each morning, I take a mix of collagen (6600 mg), MSM (2g), hyaluronic acid (100 mg), and vitamin C (1000 mg) on an empty stomach. After five weeks, I noticed a significant improvement in my skin; it has never felt so soft! My hair and nails are also growing noticeably faster. I highly recommend this product; you will see the difference for sure!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.6
- All Researches
9.5
We explored a novel injectable hydrogel designed to treat rheumatoid arthritis, which often causes joint lubrication issues and cartilage damage. This hydrogel incorporates modified hyaluronic acid and nanozymes that work together to reduce inflammation and promote cartilage repair.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
By enhancing lubrication and offering sustained anti-inflammatory effects, this treatment aims to address both early and late-stage rheumatoid arthritis effectively. Ultimately, the hydrogel presents a comprehensive approach to managing this chronic autoimmune condition.
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9
We aimed to tackle the side effects of long-term use of tofacitinib, a well-known treatment for rheumatoid arthritis. By creating hyaluronic-acid-coated transethosomes, we delivered tofacitinib directly to affected areas, enhancing efficacy while reducing side effects. Our results showed significant anti-inflammatory effects, with marked reductions in inflammatory markers in treated rats compared to conventional delivery methods. This suggests that our targeted approach may offer a promising alternative for managing rheumatoid arthritis with fewer systemic impacts.
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9
Innovative dual-drug treatment examined
We explored the potential of hyalurosomes that combine dexamethasone and luteolin as a treatment for rheumatoid arthritis. In a study using a rat model, we observed significant reductions in inflammatory markers like TNF-α and MDA, suggesting these dual drug-loaded hyalurosomes could effectively decrease inflammation and swelling in joints.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Histological analysis showed results comparable to the negative control group, indicating strong therapeutic effects. While this research is promising, further studies with human subjects are essential to confirm these findings and evaluate long-term benefits.
Read More
9
We examined a new treatment method for psoriasis using a dissolvable microneedle patch that delivers hyaluronic acid nanoparticles combined with methotrexate. This approach aims for better targeting of inflammatory skin cells while reducing side effects associated with traditional therapies. In our study with a mouse model, just one application of the patch led to a significant decrease in skin thickening and inflammation over a week. The results suggest that this innovative delivery method could improve treatment outcomes for some psoriasis patients.
Read More
9
Hyaluronic acid shows promise in RA
We synthesized a unique nanocomposite, HA-PBA-TiO, designed specifically for treating rheumatoid arthritis (RA). This innovative material shows impressive capabilities, such as boosting oxygen levels and reducing harmful reactive oxygen species in inflamed joints through photocatalytic reactions.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Our experiments demonstrated that when these nanoparticles target RA-affected areas, they help control excessive cell growth and improve the local environment. The results suggest that this approach offers a promising avenue for RA treatment, with effective outcomes backed by our testing.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 31 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
8.5
Joint mobility improved
74 people found this helpful
I have taken Hyaluronic acid 100 mg from Now for 1.5 years, a tablet daily after meals. I take it after other supplements to improve cartilage quality, joint mobility, and skin hydration while reducing wrinkles. I exercise regularly and maintain an active lifestyle. Hyaluronic acid helps alleviate stress on my joints, and I recommend it for daily use thanks to its quality and performance, especially after the age of 35.
Read More
9
Reduced wrinkles
14 people found this helpful
I really like this product! My joints feel much better, and it's visibly improved my skin, leading to far fewer wrinkles. I've just ordered some facial cream as well; I like it! The delivery from iHerb is outstanding.
Read More
9
Smoother skin
8 people found this helpful
Awesome product!! Two months ago, I purchased hyaluronic acid with collagen and MSM powder to enhance my skin, nails, joints, and cartilage. Each morning, I take a mix of collagen (6600 mg), MSM (2g), hyaluronic acid (100 mg), and vitamin C (1000 mg) on an empty stomach. After five weeks, I noticed a significant improvement in my skin; it has never felt so soft! My hair and nails are also growing noticeably faster. I highly recommend this product; you will see the difference for sure!
Read More
7.5
No side effects
8 people found this helpful
Great product! I ordered it alongside Glucosamine and collagen for my parents' joint health. There are no side effects, and they are pleased with the evident results. The stiffness has subsided, and they feel fantastic! I reiterate, a comprehensive approach is vital—simply taking hyaluronic acid alone won’t suffice.
Read More
8
Improved mobility
5 people found this helpful
This is Uleto! I have been suffering from knee arthrosis for many years. I started taking hyaluronic acid along with collagen enriched with vitamin C about four months ago, and I take it on an empty stomach, approximately 30 minutes before breakfast. Most importantly, I ensure I drink plenty of purified water and adjust my diet, emphasising protein intake. Since starting this regimen, I find it easier to walk; one knee has stopped hurting and no longer crunches! Additionally, my skin has become clearer and more nourished, and my hair looks livelier. I was so impressed that I even ordered it for my mother.
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Frequently Asked Questions
7.5
Eliminated discomfort
23 people found this helpful
This product is working! I purchased it to enhance my skin condition and alleviate discomfort in my joints. After ten days, I forgot my joint problems. However, once I stopped taking it, the discomfort returned. Regarding my skin, there is a clear improvement; there's no doubt about that.
7.5
Skin glowing
1 people found this helpful
I ordered this to complement collagen for my joints. After a month of use, I noticed positive effects within a week: my joints stopped aching and my skin appears tightened and glowing. I'm pleased, so I've ordered more.
8
Improved mobility
5 people found this helpful
This is Uleto! I have been suffering from knee arthrosis for many years. I started taking hyaluronic acid along with collagen enriched with vitamin C about four months ago, and I take it on an empty stomach, approximately 30 minutes before breakfast. Most importantly, I ensure I drink plenty of purified water and adjust my diet, emphasising protein intake. Since starting this regimen, I find it easier to walk; one knee has stopped hurting and no longer crunches! Additionally, my skin has become clearer and more nourished, and my hair looks livelier. I was so impressed that I even ordered it for my mother.
7.5
Joint pain alleviated
2 people found this helpful
I’m 47 and have been concerned about aging, searching for elixirs of youth. Although I didn’t see dramatic changes in my skin, remarkably, my knee pain has vanished! I am now able to resume training and squats. I plan to order for my husband too. Highly recommend!
9
Better sleep quality
2 people found this helpful
Changed my life. With my arthritis, getting a good night's sleep was a struggle. After about a month of taking hyaluronic acid, I now sleep soundly without restlessness. My joints feel much better, allowing me to relax and achieve deep sleep easily. The product is reasonably priced and arrived quickly after I ordered it.
9
Reduced wrinkles
14 people found this helpful
I really like this product! My joints feel much better, and it's visibly improved my skin, leading to far fewer wrinkles. I've just ordered some facial cream as well; I like it! The delivery from iHerb is outstanding.
7.5
Well hydrated skin
1 people found this helpful
I am very happy with this product. It’s well packaged, and I find that my skin is well hydrated and more elastic. I've ordered it multiple times as it has become essential to my daily vitamin regimen.
9
Smoother skin
8 people found this helpful
Awesome product!! Two months ago, I purchased hyaluronic acid with collagen and MSM powder to enhance my skin, nails, joints, and cartilage. Each morning, I take a mix of collagen (6600 mg), MSM (2g), hyaluronic acid (100 mg), and vitamin C (1000 mg) on an empty stomach. After five weeks, I noticed a significant improvement in my skin; it has never felt so soft! My hair and nails are also growing noticeably faster. I highly recommend this product; you will see the difference for sure!
9
Better wellbeing
7 people found this helpful
I believe hyaluronic acid helps maintain tissue condition. To maximise the effects, I suggest combining it with collagen and CoQ10. The results on my appearance and overall wellbeing improved significantly after the course.
7.5
No side effects
8 people found this helpful
Great product! I ordered it alongside Glucosamine and collagen for my parents' joint health. There are no side effects, and they are pleased with the evident results. The stiffness has subsided, and they feel fantastic! I reiterate, a comprehensive approach is vital—simply taking hyaluronic acid alone won’t suffice.
8.5
Joint mobility improved
74 people found this helpful
I have taken Hyaluronic acid 100 mg from Now for 1.5 years, a tablet daily after meals. I take it after other supplements to improve cartilage quality, joint mobility, and skin hydration while reducing wrinkles. I exercise regularly and maintain an active lifestyle. Hyaluronic acid helps alleviate stress on my joints, and I recommend it for daily use thanks to its quality and performance, especially after the age of 35.
0
No improvement
1 people found this helpful
I took this hyaluron with added vitamin C, but it showed zero effect! I won't order it again; injections are far better, and they last six months without needing additional treatments.
9
Melatonin-hyalurosomes improve joint healing
We explored the potential of using melatonin encapsulated in hyalurosomes combined with a thermosensitive hydrogel for managing rheumatoid arthritis. This study involved testing the effectiveness of this treatment in a rat model of arthritis.
Our results showed that the melatonin-hyalurosomes in the hydrogel significantly improved joint healing and cartilage repair compared to standard hydrogel treatments. While as effective as traditional approaches, this method looks promising due to its minimal side effects.
Our results showed that the melatonin-hyalurosomes in the hydrogel significantly improved joint healing and cartilage repair compared to standard hydrogel treatments. While as effective as traditional approaches, this method looks promising due to its minimal side effects.
8
Nanoparticles show promise for RA
We explored the effectiveness of a new drug delivery system using hyaluronic acid to target rheumatoid arthritis (RA) cells. This system utilizes nanoparticles that can enter specifically activated cells in a joint environment while being stimulated by near-infrared light.
The study showed that this innovative approach successfully inhibited the proliferation and movement of cell types associated with RA. Importantly, safety tests indicated the nanoparticles were non-toxic to normal cells.
However, the impact on overall RA symptoms and functionality remains unclear, indicating further research is needed.
The study showed that this innovative approach successfully inhibited the proliferation and movement of cell types associated with RA. Importantly, safety tests indicated the nanoparticles were non-toxic to normal cells.
However, the impact on overall RA symptoms and functionality remains unclear, indicating further research is needed.
8
Hyaluronic acid benefits uveitis treatment
We investigated how hyaluronic acid-curcumin nanoparticles (HA-CUR NPs) could help prevent autoimmune uveitis progression. Our research points to these nanoparticles having impressive antioxidant properties, helping counter inflammation and oxidative stress that drive uveitis. They appear to target specific receptors and activate protective cellular pathways, leading to reduced damage to the retina and enhanced blood flow in ocular areas. This suggests that HA-CUR NPs could be a promising new option for treating autoimmune-related eye conditions, although traditional treatments have had serious side effects.
References
- He H, Zhang Q, Zhang Y, Qu S, Li B, et al. Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy. Nat Commun. 2025;16:2768. doi:10.1038/s41467-025-58059-z
- Tang W, Huang X, Yi YD, Cao F, Deng M, et al. Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway. J Nanobiotechnology. 2025;23:89. doi:10.1186/s12951-024-03082-3
- Chowdary P, Puppala ER, Putta CL, Maddila JR, Pulavarthy V, et al. Hyaluronic-Acid-Functionalized Tofacitinib Loaded Transethosomes for Targeted Drug Delivery in Rheumatoid Arthritis. ACS Appl Bio Mater. 2025;8:1594. doi:10.1021/acsabm.4c01743
- Zewail M, Gaafar PME, Abbas H, Elsheikh MA. Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone. Colloids Surf B Biointerfaces. 2025;249:114497. doi:10.1016/j.colsurfb.2025.114497
- Zeng Y, Wu L, Jiang X, Hu Y, Jin Y, et al. Self-assembled hyaluronic acid nanoparticles delivered by polymeric microneedles for targeted and long-acting therapy of psoriasis. Int J Pharm. 2025;669:125073. doi:10.1016/j.ijpharm.2024.125073
- Liu X, Chen X, Fei Y, Zhang J, Yue O, et al. Locally Injectable, ROS-Scavenging, and ROS-/pH-Responsive Polymeric-Micelles-Embedded Hydrogels for Precise Minimally Invasive and Long-Lasting Rheumatoid Therapy. Adv Healthc Mater. 2025;14:e2403579. doi:10.1002/adhm.202403579
- Papp FR, Katko M, Csiki R, Galgoczi E, Molnar Z, et al. Characteristics of Hyaluronan Metabolism During Myofibroblast Differentiation in Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2024;65:13. doi:10.1167/iovs.65.13.13
- Chao M, Hua Z, Zhu J, Wu G, Fan L, et al. Hyaluronic acid modified prussian blue analogs/TiO₂ janus nanostructures through efficient charge separation to enhance photocatalytic-driven dual gas for achieve multimodal treatment of rheumatoid arthritis. Int J Biol Macromol. 2024;281:136567. doi:10.1016/j.ijbiomac.2024.136567
- Li Y, Wang X, Gao Y, Zhang Z, Liu T, et al. Hyaluronic acid-coated polypeptide nanogel enhances specific distribution and therapy of tacrolimus in rheumatoid arthritis. J Nanobiotechnology. 2024;22:547. doi:10.1186/s12951-024-02784-y
- Xu M, Fu T, Zhang C, An Z, Yan J, et al. Prolonged, staged, and self-regulated methotrexate release coupled with ROS scavenging in an injectable hydrogel for rheumatoid arthritis therapy. J Control Release. 2024;375:60. doi:10.1016/j.jconrel.2024.08.046
- Deng YS, Shen XY, Long MT, Zheng H, Li B, et al. [MMPs/pH synergically responsive XTS-Prussian blue nanoparticles inhibiting proliferation and migration of RAFLS assisted with laser irradiation]. Zhongguo Zhong Yao Za Zhi. 2024;49:2906. doi:10.19540/j.cnki.cjcmm.20240304.303
- Makled S, Abbas H, Ali ME, Zewail M. Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route. Int J Pharm. 2024;661:124449. doi:10.1016/j.ijpharm.2024.124449
- Liu X, Zhang Q, Cao Y, Hussain Z, Xu M, et al. An Injectable Hydrogel Composing Anti-Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis. Adv Healthc Mater. 2024;13:e2304668. doi:10.1002/adhm.202304668
- Zhu H, Huang D, Wang J, Zhao Y, Sun L. Viral Mimicking Polyplexes as Hierarchical Unpacking Vectors for Rheumatoid Arthritis Treatment. Adv Sci (Weinh). 2024;11:e2402888. doi:10.1002/advs.202402888
- Lee S, Choi S, Kim MS. Intra-articular hydrogel formulation prolongs the in vivo stability of Toll-like receptor antagonistic peptides for rheumatoid arthritis treatment. J Control Release. 2024;372:467. doi:10.1016/j.jconrel.2024.06.034
- Liu Y, Luo H, Liu B, Zhou T, Zhang Z, et al. Biomimetic NO Scavenging Hyaluronic Acid Nanoparticles Enable Targeted Delivery of MTX and Integrated Management of Rheumatoid Arthritis. Biomacromolecules. 2024;25:4557. doi:10.1021/acs.biomac.4c00556
